\u6211\u4eec\u7684\u8eab\u4f53\u548c\u7cbe\u795e\u72b6\u6001\u4e4b\u95f4\u7684\u8054\u7cfb\u975e\u5e38\u7d27\u5bc6\uff0c\u4ee5\u81f3\u4e8e\u4e13\u5bb6\u57281930\u5e74\u4ee3\u5c06\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u5f52\u7c7b\u4e3a\u4e00\u79cd\u5fc3\u8eab\u75be\u75c5\u3002\u8fd9\u5c31\u662f\u60a3\u6709\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u4eba\u60a3\u6291\u90c1\u75c7\u7684\u51e0\u7387\u9ad8\u4e00\u500d\u7684\u539f\u56e0\uff0c\u5e76\u4e14\u8fd9\u4f7f\u5f97\u538b\u529b\u6210\u4e3a\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u590d\u53d1\u7684\u4e3b\u8981\u8bf1\u56e0\u4e4b\u4e00\u3002<\/p>\n
\u5bf9\u4e8e\u5982\u6b64\u591a\u7684\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u60a3\u8005\uff0c\u8fd9\u79cd\u8054\u7cfb\u5bfc\u81f4\u6076\u6027\u5faa\u73af\uff0c\u901a\u5e38\u7c7b\u4f3c\u4e8e\u4ee5\u4e0b\u60c5\u51b5\uff1a<\/p>\n
\u538b\u529b\u5927\u7684\u4e8b\u4ef6\u2013> UC\u75c7\u72b6\u53d1\u4f5c\u2013>\u6291\u90c1\/\u7126\u8651\u2013>UC\u75c7\u72b6\u53d8\u5f97\u66f4\u4e25\u91cd\u2013>
\n\u6291\u90c1\/\u7126\u8651\u52a0\u5267\u2013> \u65e0\u6cd5\u6267\u884c\u65e5\u5e38\u4efb\u52a1\u548c\u63a7\u5236UC\u75c7\u72b6<\/p>\n
\u80a0\u9053\u4e2d\u7684\u5fae\u751f\u7269\u7fa4\u4e0e\u6291\u90c1\u75c7\u7684\u5173\u7cfb\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u5f15\u8d77\u7684\u75bc\u75db\u548c\u8179\u6cfb\u4e00\u6837\u3002<\/p>\n
\u8bf7\u7ee7\u7eed\u9605\u8bfb\uff0c\u6211\u4eec\u5c06\u6df1\u5165\u63a2\u8ba8\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u6240\u6709\u7ec6\u8282\u3002<\/p>\n
\u4ec0\u4e48\u662f\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff1f<\/b><\/p>\n
\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\uff08UC\uff09\u662f\u4e00\u79cd\u6162\u6027\u708e\u75c7\u6027\u80a0\u75c5\uff08IBD\uff09\uff0c\u4ee5\u5927\u80a0\uff08\u76f4\u80a0\u548c\u7ed3\u80a0\uff09\u53d1\u708e\u4e3a\u7279\u5f81\u3002\u708e\u75c7\u5728\u79f0\u4e3a\u7c98\u819c\u7684\u6d88\u5316\u9053\u6700\u5185\u5c42\u4ee5\u8fde\u7eed\u7684\u5f62\u5f0f\u51fa\u73b0\u3002<\/p>\n
UC \u67094\u79cd\u4e0d\u540c\u7c7b\u578b\uff08\u6bcf\u79cd\u7c7b\u578b\u5747\u4ee5\u708e\u75c7\u7684\u786e\u5207\u4f4d\u7f6e\u547d\u540d\uff09\uff1a<\/p>\n
1. \u6e83\u75a1\u6027\u76f4\u80a0\u708e\u2013\u76f4\u80a0\uff08\u6700\u5e38\u89c1\uff09<\/p>\n
2. \u76f4\u80a0\u4e59\u72b6\u7ed3\u80a0\u708e\u2013\u76f4\u80a0\u548c\u4e59\u72b6\u7ed3\u80a0<\/p>\n
3. \u5de6\u4fa7\u7ed3\u80a0\u708e\u2013\u5de6\u4fa7\u7ed3\u80a0\u708e\u662f\u6307\u53d1\u708e\u5728\u7ed3\u80a0\u5de6\u4fa7<\/p>\n
4. \u5168\u7ed3\u80a0\u708e\u2013\u6574\u4e2a\u7ed3\u80a0<\/p>\n
\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u75c7\u72b6\u901a\u5e38\u968f\u65f6\u95f4\u7f13\u6162\u53d1\u5c55\u3002<\/p>\n
\u5728\u6d3b\u52a8\u9636\u6bb5\uff0c\u75c7\u72b6\u5305\u62ec\uff1a<\/p>\n
\u8179\u6cfb\uff0c\u7ecf\u5e38\u5e26\u8840\u6216\u8113\u6db2<\/p>\n
\u8179\u90e8\u75bc\u75db\u548c\u7ede\u75db<\/p>\n
\u6e83\u75a1\uff08\u5728\u708e\u75c7\u5df2\u6740\u6b7b\u7ed3\u80a0\u5185\u819c\u7ec6\u80de\u7684\u5730\u65b9\u5f62\u6210\uff09\u4f53\u91cd\u4e0b\u964d\uff08\u7531\u4e8e\u8fdb\u98df\u65f6\u75bc\u75db\u548c\u5438\u6536\u95ee\u9898\uff09<\/p>\n
\u76f4\u80a0\u75bc\u75db<\/p>\n
\u75b2\u52b3\u548c\u53d1\u70e7<\/p>\n
\u773c\u75db\uff0c\u76ae\u75b9\u548c\u5173\u8282\u75db\uff08\u8f83\u4e0d\u5e38\u89c1\uff09<\/p>\n
\u5c06\u8fd1300\u4e07\u7f8e\u56fd\u4eba\u60a3\u6709\u708e\u75c7\u6027\u80a0\u75c5\uff0c\u5176\u4e2d\u8d85\u8fc790\u4e07\u60a3\u6709\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u3002UC\u5bf9\u6bcf\u4e2a\u4eba\u7684\u5f71\u54cd\u4e0d\u540c\uff0c\u4ece\u8f7b\u5ea6\u75c7\u72b6\u4e00\u76f4\u5230\u5a01\u80c1\u751f\u547d\u7684\u7a0b\u5ea6\u4e0d\u7b49\u3002\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u53ef\u4ee5\u51fa\u73b0\u5728\u4efb\u4f55\u5e74\u9f84\uff0c\u4f46\u901a\u5e38\u572815\u523030\u5c81\u4e4b\u95f4\u8fbe\u5230\u9ad8\u5cf0\u3002\u5bf9\u4e8e\u6cbb\u7597\u8fd9\u79cd\u4ee4\u4eba\u4e0d\u65ad\u865a\u5f31\u7684\u6162\u6027\u75c5\uff0c\u5c3d\u65e9\u53d1\u73b0\u662f\u6700\u7406\u60f3\u7684\u3002<\/p>\n
\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u5982\u4f55\u8bca\u65ad\uff1f<\/b><\/p>\n
\u4f7f\u7528\u4e00\u7cfb\u5217\u6d4b\u8bd5\u548c\u5de5\u5177\u6765\u6392\u9664\u5176\u4ed6\u60c5\u51b5\u5e76\u786e\u8ba4UC\u8bca\u65ad\u3002\u6700\u5e38\u89c1\u7684\u6d4b\u8bd5\u662f\uff1a<\/p>\n
\u7ed3\u80a0\u955c\u68c0\u67e5\u6216\u4e59\u72b6\u7ed3\u80a0\u955c\u68c0\u67e5\u2013 \u5c06\u7ec6\u7ec6\u7684\uff0c\u88c5\u6709\u6444\u50cf\u5934\u7684\u8f6f\u7ba1\u63d2\u5165\u809b\u95e8\uff0c\u4ee5\u68c0\u6d4b\u7ed3\u80a0\u548c\u76f4\u80a0\u7684\u4efb\u4f55\u708e\u75c7\uff0c\u6e83\u75a1\u6216\u51fa\u8840\u3002\u5728\u68c0\u67e5\u8fc7\u7a0b\u4e2d\u4e5f\u53ef\u4ee5\u53d6\u4e00\u5c0f\u90e8\u5206\u7ec4\u7ec7\u6837\u672c\uff08\u6d3b\u68c0\uff09\u7528\u4e8e\u5b9e\u9a8c\u5ba4\u5206\u6790\u3002<\/p>\n
CT\u626b\u63cf\u2013 \u8be5\u6d4b\u8bd5\u7528\u4e8e\u786e\u5b9a\u662f\u5426\u5b58\u5728\u4efb\u4f55\u5e76\u53d1\u75c7\uff0c\u5e76\u4e14\u8fd8\u53ef\u4ee5\u663e\u793a\u6709\u591a\u5c11\u7ed3\u80a0\u53d1\u708e\u3002<\/p>\n
\u8840\u6db2\u68c0\u67e5\u2013 \u8840\u6db2\u68c0\u67e5\u7528\u4e8e\u68c0\u67e5\u662f\u5426\u6709\u8db3\u591f\u7684\u94c1\u6c34\u5e73\uff0c\u56e0\u4e3a\u94c1\u7f3a\u4e4f\u662f\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u5e38\u89c1\u5e76\u53d1\u75c7\uff08\u7531\u4e8e\u6162\u6027\u8179\u6cfb\u5bfc\u81f4\u8840\u6db2\u6d41\u5931\uff09\u3002<\/p>\n
\u7caa\u4fbf\u6837\u672c\u2013 \u7caa\u4fbf\u6837\u672c\u53ef\u4ee5\u5e2e\u52a9\u6392\u9664\u7ec6\u83cc\u6216\u5bc4\u751f\u866b\u611f\u67d3\uff0c\u4ee5\u53ca\u68c0\u6d4b\u767d\u7ec6\u80de\uff08WBC\uff09\u3002\u767d\u7ec6\u80de\u8ba1\u6570\u9ad8\u8868\u660e\u8eab\u4f53\u67d0\u5904\u6709\u708e\u75c7\uff0c\u53ef\u80fd\u662f\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u5f81\u5146\u3002<\/p>\n
\u767d\u7ec6\u80de\u68c0\u6d4b\uff08WBC\u626b\u63cf\uff09\u2013 \u767d\u7ec6\u80de\u88ab\u5438\u5f15\u5230\u708e\u75c7\u90e8\u4f4d\uff0c\u8be5\u6d4b\u8bd5\u53ef\u4ee5\u5e2e\u52a9\u786e\u5b9a\u5b83\u4eec\u805a\u96c6\u7684\u4f4d\u7f6e\u3002WBC\u53d6\u81ea\u6837\u54c1\uff0c\u5e76\u5c06\u8d34\u6709\u65e0\u5bb3\u91cf\u7684\u653e\u5c04\u6027\u7269\u8d28\u6ce8\u5165\u4f53\u5185\uff0c\u4f7f\u7528\u4e13\u7528\u6444\u50cf\u5934\u67e5\u770b\u653e\u5c04\u6027\u767d\u7ec6\u80de\u5728\u4f55\u5904\u4f20\u64ad\u3002<\/p>\n
\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u662f\u9057\u4f20\u75c5\u5417\uff1f<\/b><\/p>\n
\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u60a3\u8005\u4e2d\u5c06\u8fd115\uff05\u7684\u4eba\u662f\u4e00\u7ea7\u4eb2\u621a\uff0c\u4e5f\u60a3\u6709\u8fd9\u79cd\u75be\u75c5\u3002\u5728\u540c\u5375\u53cc\u80de\u80ce\u4e2d\uff0cUC\u7684\u53d1\u751f\u7387\u7ea6\u4e3a16\uff05\uff0c\u800c\u5728\u5f02\u5375\u53cc\u80de\u80ce\u4e2d\uff0c\u8be5\u6bd4\u7387\u4e0b\u964d\u52304\uff05\u3002<\/p>\n
\u786e\u5207\u7684\u57fa\u56e0\u5c1a\u5f85\u786e\u5b9a\uff0c\u4f46\u4ee5\u4e0b\u91cd\u70b9\u4ecb\u7ecd\u4e86\u6709\u5173\u9057\u4f20\u5b66\u548c\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u6700\u65b0\u7814\u7a76\uff1a<\/p>\n
\u5728UC\u4e2d\u5df2\u7ecf\u9274\u5b9a\u51fa\u603b\u5171163\u79cd\u9ad8\u98ce\u9669\u57fa\u56e0\/\u4f4d\u70b9\u3002\u4e00\u9879\u9488\u5bf929,838\u540dIBD\u60a3\u8005\uff0816,902\u540d\u514b\u7f57\u6069\u6c0f\u75c5\u548c12,597\u540dUC\u75c5\u60a3\uff09\u7684\u5927\u578b\u7814\u7a76\u6700\u8fd1\u53d1\u73b0\u4e86\u4e09\u4e2a\u4e0e\u708e\u75c7\u6027\u80a0\u75c5\u76f8\u5173\u7684\u65b0\u57fa\u56e0\u5ea7\uff1aNOD2\uff0cMHC\u548cMST1 3p21\u3002<\/p>\n
IL-13\u662f\u8d1f\u8d23UC\u708e\u75c7\u548c\u6162\u6027\u75c7\u72b6\u7684\u4e3b\u8981\u767d\u4ecb\u7d20\u3002\u5b83\u4f1a\u5bfc\u81f4\u4e0a\u76ae\u5c4f\u969c\u635f\u4f24\uff0c\u964d\u4f4e\u7c98\u819c\u4fee\u590d\u7684\u901f\u5ea6\uff0c\u5e76\u5bfc\u81f4\u80a0\u9053\u7d27\u5bc6\u8fde\u63a5\u7684\u6539\u53d8\u3002\u5411\u7ec6\u80de\u57f9\u517b\u7269\u4e2d\u6dfb\u52a0IL-13\u53ef\u589e\u52a0\u5927\u5206\u5b50\uff08\u5982\u7518\u9732\u9187\u548c\u4e73\u679c\u7cd6\uff09\u7684\u901a\u91cf\uff0c\u5e76\u4e14\u8fd8\u4f1a\u5f71\u54cd\u7c98\u819c\u4fee\u590d\u7684\u901f\u5ea630\uff05\u3002<\/p>\n
IL-10\u662f\u4e00\u79cd\u6297\u708e\u7ec6\u80de\u56e0\u5b50\uff0c\u5bf9UC\u5177\u6709\u79ef\u6781\u4f5c\u7528\u3002\u5b83\u6291\u5236\u67d0\u4e9b\u5f15\u8d77\u708e\u75c7\u7684\u56e0\u5b50\uff08\u5373TNF-\u03b1\uff09\u7684\u4ea7\u751f\uff0cIL-10\u7684\u5931\u6d3b\u88ab\u8bc1\u660e\u53ef\u5f15\u8d77\u5c0f\u9f20\u6162\u6027\u56de\u80a0\u7ed3\u80a0\u708e\uff08\u4e00\u79cd\u7279\u5b9a\u7684UC\uff09\uff0c\u8868\u660e\u5176\u5728\u7c98\u819c\u5c42\u5185\u5177\u6709\u4fdd\u62a4\u4f5c\u7528\u3002<\/p>\n
\u90a3\u4e48\uff0c\u8fd9\u610f\u5473\u7740\u4ec0\u4e48\uff1f\u9057\u4f20\u5b66\u5728UC\u4e2d\u5f53\u7136\u8d77\u7740\u4e00\u5b9a\u7684\u4f5c\u7528\uff0c\u4f46\u662f\u4ec5\u9057\u4f20\u5b66\u8fd8\u4e0d\u8db3\u4ee5\u89e3\u91ca\u4e3a\u4ec0\u4e48IBD\u5df2\u4ece1999\u5e74\u7684200\u4e07\u589e\u52a0\u5230\u4eca\u5929\u7684300\u4e07\u3002<\/p>\n
\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u8bf1\u56e0<\/b><\/p>\n
\u73af\u5883\u56e0\u7d20\u662fIBD\u4e0a\u5347\u7684\u4e00\u4e2a\u91cd\u8981\u539f\u56e0\uff0c\u56e0\u4e3a\u5b83\u4eec\u53ef\u4ee5\u6253\u5f00\u9057\u4f20\u6613\u611f\u4eba\u7fa4\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u7684\u57fa\u56e0\u3002<\/p>\n
\u6e83\u75a1\u6027\u7ed3\u80a0\u708e\u6700\u5e38\u89c1\u7684\u73af\u5883\u8bf1\u56e0\u662f\uff1a<\/p>\n
\u7ef4\u751f\u7d20D\u7f3a\u4e4f\u75c7- \u7ef4\u751f\u7d20D \u56e0\u5176\u5728\u9aa8\u9abc\u5065\u5eb7\u4e2d\u7684\u4f5c\u7528\u800c\u5e7f\u53d7\u6b22\u8fce\uff0c\u7531\u4e8e\u5176\u5728\u6162\u6027\u75be\u75c5\u4e2d\u7684\u4f5c\u7528\u800c\u8fc5\u901f\u83b7\u5f97\u8ba4\u53ef\u3002\u8fd9\u9879\u5bf9504\u540dIBD\u60a3\u8005\u7684\u7814\u7a76\u53d1\u73b0\uff0c\u8f83\u4f4e\u7684\u7ef4\u751f\u7d20D\u6c34\u5e73\u4e0e\u75be\u75c5\u6d3b\u52a8\u7684\u9002\u5ea6\u589e\u52a0\u6709\u5173\u3002\u8865\u5145\u7ef4\u751f\u7d20D\u540e2\u5468\u5185\uff0c\u80a0\u9053\u708e\u75c7\u7684\u4e25\u91cd\u7a0b\u5ea6\u6709\u6240\u6539\u5584\u3002<\/p>\n
\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\uff08NSAIDS\uff09\u2013 \u8fd9\u9879\u7814\u7a76\u663e\u793a\u4e86\u975e\u753e\u4f53\u7c7b\u6297\u708e\u836f\u5982\u4f55\u5f71\u54cd\u80a0\u9053\u83cc\u7fa4\uff0c\u6211\u4eec\u73b0\u5728\u77e5\u9053\u8fd9\u5bf9\u4e8e\u6211\u4eec\u7684\u6574\u4f53\u5065\u5eb7\u6781\u4e3a\u91cd\u8981\u3002\u53e6\u4e00\u9879\u7814\u7a76\u8868\u660e\uff0c\u9ad8\u5242\u91cf\uff0c\u6301\u7eed\u65f6\u95f4\u957f\u548cNSAIDs\u9891\u7e41\u4f7f\u7528\u4e0eUC \u98ce\u9669\u589e\u52a0\u6709\u5173\u3002<\/p>\n
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